Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are three closely related pathogens. They all possess the gene coding for the Bordetella type three secretion system effector A (bteA) toxin that became a focus of interest since …
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among …
We performed a retrospective study of pertussis patients seen during the period July 2007-December 2011. All patients were microbiologically confirmed through polymerase chain reaction (PCR) or culture. Thirtyone patients with positive Bordetella spp. culture …
U.S. national surveillance data show that the use of culture for pertussis diagnostics has sharply declined, while PCR is now the most common testing method. PCR testing for pertussis is rapid and sensitive, but …
Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa are less protective than the more reactogenic whole …
This study aimed to evaluate the performance of polymerase chain reaction (PCR) methods used for the diagnosis of pertussis in laboratories within Europe in 2011. National reference laboratories in 25 European countries …
The exacerbated induction of innate immune response in airways can abrogate diverse lung infections by a phenomenon known as stimulated innate resistance (StIR). We have recently demonstrated that the enhancement …
Global coverage with three doses of the diphtheria, tetanus and pertussis vaccine (DTP3) increased from less than 5% in 1974 to 82% in 2009 due to worldwide focus on universal vaccination. Nonetheless, pertussis remains …
BACKGROUND: Filamentous hemagglutinin (FHA) is one of the most important immunoprotective antigens of Bordetella pertussis (B. pertussis) and a major component of the acellular pertussis vaccine. In the present study, three overlapping recombinant fragments from …
Potential underestimation of the health system burden of pertussis was investigated by linking administrative datasets including pertussisnotifications, hospitalizations and emergency department (ED) presentations for 1 304 876 children aged <15 years in NSW, Australia. From …
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