Bordetella pertussis, Bordetella parapertussis, vaccines and cycles of whooping cough

Whooping cough is a vaccine preventable disease due to Bordetella pertussis and Bordetella parapertussis. This highly contagious respiratory disease occurs through epidemic cycles every 3-5 years and vaccination didn’t change this frequency. Models suggest that the cyclic increase of susceptibles is linked to demographic differences and different vaccine coverage. However, differences in surveillance of the disease as well as adaptation of the agents of the disease to their human hosts and to vaccine pressure might also play an important role. These parameters are discussed in this review.

Authors:Bouchez V1, Guiso N2.
Journal:Pathog Dis. 2015