Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda.

We determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control.

METHODS:

In a cross-sectional study, 449 children aged 3 months to 12 years with persistent cough lasting ≥14 days were enrolled and evaluated for pertussis using DNA polymerase chain reaction (PCR) and ELISA serology tests.

RESULTS:

Pertussis prevalence was 67 (15% (95% Confidence Interval (CI): 12-18)) and 81 (20% (95% CI: 16-24)) by PCR and ELISA, respectively among 449 participating children. The prevalence was highest in children with >59 months of age despite high vaccination coverage of 94% in this age group. Study demographic and clinical characteristics were similar between pertussis and non-pertussis cases. Of the 449 children, 133 (30%) had a coughing household member and 316 (70%) did not. Among 133 children that had a coughing household member, sex of child, sharing bed with a coughing household member and having a coughing individual in the neighborhood were factors associated with pertussis. Children that had shared a bed with a coughing household individual had seven-fold likelihood of having pertussis compared to children that did not (odds ratio (OR) 7.16 (95% CI: 1.24-41.44)). Among the 316 children that did not have a coughing household member, age 40 years of age were the factors associated with pertussis. Age 59 months of age, suggesting the possibility of waning immunity. The factors associated with pertussis varied by presence or absence of a coughing household member.

Authors:Kayina V1, Kyobe S2, Katabazi FA2, Kigozi E2, Okee M2, Odongkara B3, Babikako HM4, Whalen CC5, Joloba ML2, Musoke PM1, Mupere E1.
Journal:PLoS One. 2015
Link:http://www.ncbi.nlm.nih.gov/pubmed/25874411