Do we need a new vaccine to control the re-emergence of pertussis?

Bordetella pertussis causes whooping cough and is re-emerging in developed countries despite widespread immunization with acellular pertussisvaccines (Pa), which are less effective than the whole cell vaccines that they replaced. Efficacy of Pa could be improved by switching from alum to alternative adjuvants that generate more potent cell mediated immunity.

Authors:Mills KH1, Ross PJ2, Allen AC2, Wilk MM2.

Journal:Trends Microbiol. 2014